Novel computer-aided diagnostic system for colorectal lesions by using endocytoscopy (with videos)

Gastrointest Endosc. 2015 Mar;81(3):621-9. doi: 10.1016/j.gie.2014.09.008. Epub 2014 Oct 29.


Background: Endocytoscopy enables in vivo observation of nuclei at 450× magnification during GI endoscopy, thus allowing precise prediction of lesion pathology. However, because it requires training and experience, it may be beneficial only when performed by expert endoscopists.

Objective: To develop and evaluate a novel computer-aided diagnosis system for endocytoscopic imaging (EC-CAD) of colorectal lesions.

Design: Pilot study.

Setting: University hospital.

Patients: One hundred fifty-two patients with small colorectal polyps (≤10 mm) who had undergone endocytoscopy.

Intervention: Test sets of white-light endoscopic images and endocytoscopic images from 176 small colorectal polyps (137 neoplastic and 39 non-neoplastic polyps) were assessed by EC-CAD, 2 expert endoscopists, and 2 trainee endoscopists.

Main outcome measurement: Sensitivity, specificity, and accuracy in predicting neoplastic change by EC-CAD comparing expert and trainee endoscopists.

Results: EC-CAD had a sensitivity of 92.0% and an accuracy of 89.2%; these were comparable to those achieved by expert endoscopists (92.7% and 92.3%; P = .868 and .256, respectively) and significantly higher than those achieved by trainee endoscopists (81.8% and 80.4%; P < .001 and .002, respectively). EC-CAD achieved a specificity of 79.5%; this did not differ significantly from that achieved by the experts and trainees. EC-CAD also enabled instant diagnosis, taking only 0.3 seconds for each lesion with perfect reproducibility.

Limitations: No sample size calculation.

Conclusions: EC-CAD provides fully automated instant classification of colorectal polyps with excellent sensitivity, accuracy, and objectivity. Thus, it can be a powerful tool for facilitating decision making during routine colonoscopy.

Publication types

  • Clinical Trial
  • Video-Audio Media

MeSH terms

  • Adenoma / pathology*
  • Adult
  • Aged
  • Colonoscopy / methods*
  • Colorectal Neoplasms / pathology*
  • Female
  • Humans
  • Image Interpretation, Computer-Assisted*
  • Intestinal Polyps / pathology*
  • Male
  • Middle Aged
  • Pilot Projects
  • Reproducibility of Results
  • Sensitivity and Specificity