Endoscopic hemostasis in acute esophageal variceal bleeding

Gastroenterol Clin North Am. 2014 Dec;43(4):795-806. doi: 10.1016/j.gtc.2014.08.009. Epub 2014 Sep 29.

Abstract

Acute variceal bleeding (AVB) is a milestone event for patients with portal hypertension. Esophageal varices bleed because of an increase in portal pressure that causes the variceal wall to rupture. AVB in a patient with cirrhosis and portal hypertension is associated with significant morbidity and mortality. The initial management of these patients includes proper resuscitation, antibiotic prophylaxis, pharmacologic therapy with vasoconstrictors, and endoscopic therapy. Intravascular fluid management, timing of endoscopy, and endoscopic technique are key in managing these patients. This article reviews the current endoscopic hemostatic strategies for patients with AVB.

Keywords: Acute variceal bleeding; Endoscopy; Hemostasis; Portal hypertension.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Anti-Bacterial Agents / therapeutic use
  • Blood Transfusion
  • Endoscopy, Gastrointestinal
  • Esophageal and Gastric Varices / etiology
  • Esophageal and Gastric Varices / therapy*
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Hemorrhage / therapy*
  • Hemostasis, Endoscopic*
  • Hemostatics / administration & dosage
  • Humans
  • Hypertension, Portal / complications
  • Intubation, Intratracheal
  • Ligation
  • Liver Cirrhosis / complications
  • Sclerotherapy*
  • Stents
  • Vasoconstrictor Agents / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Hemostatics
  • Vasoconstrictor Agents