Dietary models of insulin resistance

Metabolism. 2015 Feb;64(2):163-71. doi: 10.1016/j.metabol.2014.08.013. Epub 2014 Sep 10.


Insulin resistance is a significant factor in the development of type 2 diabetes mellitus, however the connection between the Western diet and the development of insulin resistance has not been fully explained. Dietary macronutrient composition has been examined in a number of articles, and diets enriched in saturated fatty acids, and possibly in fructose, appear to be most consistently associated with the development of insulin resistance. However, mechanistic insights into the metabolic effects of such diets are lacking, and merit further study.

Keywords: Carbohydrate; Dietary composition; Fat; Insulin resistance.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / metabolism
  • Diet / adverse effects*
  • Dietary Fats / adverse effects
  • Dietary Fats / metabolism
  • Energy Metabolism
  • Fructose / adverse effects
  • Fructose / metabolism
  • Humans
  • Insulin Resistance*
  • Models, Biological*


  • Dietary Fats
  • Fructose