Increased lipid peroxidation in malignant tissues of patients with colorectal cancer

Cancer. 1989 Jul 15;64(2):422-5. doi: 10.1002/1097-0142(19890715)64:2<422::aid-cncr2820640214>3.0.co;2-2.

Abstract

The authors investigated the level of lipid peroxidation and possible related phenomena in the activation of phospholipase A2 and the infiltration of granulocyte neutrophils in human colorectal cancer tissue samples. Malondialdehyde (an index of lipid peroxidation), phospholipase A2 activity, and myeloperoxidase activity (a marker of granulocyte neutrophils) were found to be increased significantly in cancerous compared with macroscopically normal tissues. They concluded that increased lipid peroxidation, phospholipase A2, and myeloperoxidase activity are associated with human colorectal cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Colorectal Neoplasms / metabolism*
  • Female
  • Humans
  • Lipid Peroxidation*
  • Male
  • Malondialdehyde / analysis
  • Middle Aged
  • Peroxidase / analysis
  • Phospholipases A / analysis
  • Phospholipases A2

Substances

  • Malondialdehyde
  • Peroxidase
  • Phospholipases A
  • Phospholipases A2