Rigor or mortis: best practices for preclinical research in neuroscience

Neuron. 2014 Nov 5;84(3):572-81. doi: 10.1016/j.neuron.2014.10.042. Epub 2014 Nov 5.


Numerous recent reports document a lack of reproducibility of preclinical studies, raising concerns about potential lack of rigor. Examples of lack of rigor have been extensively documented and proposals for practices to improve rigor are appearing. Here, we discuss some of the details and implications of previously proposed best practices and consider some new ones, focusing on preclinical studies relevant to human neurological and psychiatric disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Mental Disorders / diagnosis
  • Mental Disorders / therapy*
  • Nervous System Diseases / diagnosis
  • Nervous System Diseases / therapy*
  • Neurosciences*
  • Translational Medical Research*