The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1

Cell. 1989 Jun 16;57(6):987-96. doi: 10.1016/0092-8674(89)90337-1.

Abstract

In Aspergillus nidulans, the temperature-sensitive, recessive cell cycle mutation bimG11 causes an elevated mitotic index at restrictive temperature and an inability to complete the anaphase separation of daughter nuclei. We have shown that this mutation has an abnormally high content of nuclear phosphoproteins and that the wild-type gene encodes a type 1 protein phosphatase. We conclude that dephosphorylation of a key protein(s) is required to complete mitosis.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Anaphase*
  • Aspergillus nidulans / cytology
  • Aspergillus nidulans / genetics*
  • Base Sequence
  • Cloning, Molecular
  • Genes, Fungal*
  • Genetic Complementation Test
  • Molecular Sequence Data
  • Mutation
  • Nuclear Proteins / physiology
  • Phosphoprotein Phosphatases / genetics*
  • Phosphoproteins / physiology
  • Protein Phosphatase 1
  • RNA, Messenger / genetics
  • Spindle Apparatus / physiology

Substances

  • Nuclear Proteins
  • Phosphoproteins
  • RNA, Messenger
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 1

Associated data

  • GENBANK/M27067