Gestational syphilis and stillbirth in Latin America and the Caribbean
- PMID: 25443140
- DOI: 10.1016/j.ijgo.2014.09.017
Gestational syphilis and stillbirth in Latin America and the Caribbean
Abstract
Objective: To measure the association between gestational syphilis and stillbirth in Latin America and the Caribbean.
Methods: In a retrospective study, data on stillbirth and gestational syphilis extracted from the Sistema Informático Perinatal database were analyzed for deliveries in 11 countries between January 1, 2009, and December 31, 2012. Potential confounders were examined, and binary logistic regression analysis was performed to assess the association between gestational syphilis and stillbirth.
Results: Among 368 151 deliveries, 3875 (1.1%) were by women with a positive syphilis test, and 1461 (0.4%) were stillbirths. Among the stillbirths, 29 (2.0%) were delivered by women with a positive syphilis test. After controlling for country, congenital anomalies, gestational age at labor, maternal age, and previous stillbirth, gestational syphilis was significantly associated with stillbirth (odds ratio 1.88, 95% confidence interval 1.25-2.83; P=0.002).
Conclusion: Gestational syphilis contributes to stillbirth in Latin America and the Caribbean. Interventions targeting gestational syphilis are highly cost-effective and should be implemented across the region.
Keywords: Caribbean; Latin America; Mother-to-child transmission; Stillbirth; Syphilis.
Copyright © 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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