Keratitis caused by Absidia corymbifera in an immunocompetent male with no corneal injuries

Arch Soc Esp Oftalmol. 2015 Mar;90(3):139-41. doi: 10.1016/j.oftal.2014.02.020. Epub 2014 Nov 18.
[Article in English, Spanish]

Abstract

Case Report A healthy 55-years-old male went to emergency due to a white infiltrate in the left eye without corneal trauma which partially responds to antibiotic treatment. The infiltrate worsened by the use of topical steroids. Direct microscopic evaluation and Gram stain are a valuable diagnostic tool for the detection of Absidia filaments. There is a successful treatment with anphotericin and posaconazole. Discussion Keratitis caused by Zygomicetes are unusual. This is a rare condition in healthy patients with no corneal trauma. The treatment with amphotericin and posaconazole are synergistic against filamentous fungi.

Keywords: Absidia corymbifera; Amphotericin; Anfotericina; Fungal keratitis; Queratitis fúngica.

MeSH terms

  • Absidia / drug effects
  • Absidia / isolation & purification*
  • Administration, Ophthalmic
  • Adrenal Cortex Hormones / adverse effects
  • Amphotericin B / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Antifungal Agents / therapeutic use
  • Combined Modality Therapy
  • Corneal Transplantation
  • Corneal Ulcer / drug therapy
  • Corneal Ulcer / etiology*
  • Corneal Ulcer / microbiology
  • Corneal Ulcer / surgery
  • Drug Therapy, Combination
  • Humans
  • Immunocompetence
  • Male
  • Middle Aged
  • Mucormycosis / diagnosis
  • Mucormycosis / drug therapy
  • Mucormycosis / microbiology*
  • Ophthalmic Solutions
  • Staining and Labeling
  • Triazoles / therapeutic use
  • Voriconazole / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents
  • Antifungal Agents
  • Ophthalmic Solutions
  • Triazoles
  • posaconazole
  • Amphotericin B
  • Voriconazole