[SD-OCT As screening test for hydroxychloroquine retinopathy: The «flying saucer» sign]

Abstract

Case reports: Two asymptomatic women treated with hydroxychloroquine 200mg every day for 8 and 16 years developed retinal toxicity.

Discussion: Patient 1 was found to have a normal fundus and autofluorescence examination. Patient 2 was found to have a completely normal fundus examination. Fluorescein angiography shows parafoveal hyperfluorescence, and autofluorescence shows a minimal decrease in signal in the same region. In both patients the SD-OCT shows disruption of the ellipsoid zone in parafoveal region («flying saucer» sign). SD-OCT findings in the retina can identify hydroxychloroquine retinopathy in asymptomatic patients.

Keywords: Hidroxichloroquina; Hydroxychloroquine; Maculopathy; Maculopatía; Prueba de detección; SD-OCT; Screening test; Signo «del platillo volante»; «Flying saucer» sign.