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. 2014 Oct;12(10):777-81.
doi: 10.1016/S1875-5364(14)60118-7. Epub 2014 Oct 31.

Role of Ocimum Sanctum Leaf Extract on Dietary Supplementation in the Transgenic Drosophila Model of Parkinson's Disease

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Role of Ocimum Sanctum Leaf Extract on Dietary Supplementation in the Transgenic Drosophila Model of Parkinson's Disease

Yasir Hasan Siddique et al. Chin J Nat Med. .

Abstract

Aim: To evaluate the effect of Ocimum sanctum leaf extract on the dietary supplementation in the transgenic Drosophila model of Parkinson's disease.

Method: The effect of Ocimum sanctum leaf extract was studied on the transgenic Drosophila model of flies expressing normal human alpha synuclein (h-αs) in the neurons. O. sanctum extract at final concentrations of 0.042 8 × 10(-4), 0.87 × 10(-4), and 1.85 × 10(-4) g·mL(-1) of diet were established and the flies were allowed to feed for 21 days. The climbing assay and lipid peroxidation were taken as parameters for the study.

Results: The supplementation of O. sanctum extract showed a dose-dependent significant delay in the loss of climbing ability and reduction in oxidative stress in the brain of PD model flies.

Conclusion: The results of the present study showed that the O. sanctum extract is potent in reducing the PD symptoms in transgenic Drosophila model.

Keywords: Climbing assay; Drosophila model; Lipid peroxidation; Ocimum sanctum; Parkinson's disease.

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