Pregnancy outcome of early multifetal pregnancy reduction: triplets to twins versus triplets to singletons

Reprod Biomed Online. 2014 Dec;29(6):717-21. doi: 10.1016/j.rbmo.2014.09.003. Epub 2014 Sep 16.


Multifetal pregnancy reduction (MPR) of triplets to twins results in improved pregnancy outcomes compared with triplet gestations managed expectantly. Perinatal outcomes of early transvaginal MPR from triplets to twins were compared with reduction from triplets to singletons. Seventy-four trichorionic triplet pregnancies that underwent early transvaginal MPR at 6-8 weeks gestation were included. Cases were divided into two groups according to the initial procedure: reduction to twin (n = 55) or to singleton (n = 19) gestations. Infants from triplet pregnancies reduced to twins were delivered earlier (36.6 versus 37.9 weeks; P = 0.04) and had lower mean birth weights (2364 g versus 2748 g; P = 0.02) compared with those from triplets reduced to singleton gestations. The rates of pregnancy loss before 24 weeks (3.6% versus 5.3%), as well as of preterm delivery before 32 and 34 weeks of gestation (0% versus 5.3% and 7.3% versus 5.3%, respectively) were similar between the twin and singleton pregnancies. No significant difference was found in the prevalence of gestational diabetes (15.1% versus 5.6%) or gestational hypertension (24.5% versus 16.7%) between the groups. Selective reduction of triplet pregnancies to singleton rather than twin gestations is associated with improved outcomes.

Keywords: MPR; early reduction; transvaginal fetal reduction; triplets.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Birth Weight
  • Cohort Studies
  • Female
  • Gestational Age
  • Humans
  • Israel
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy Reduction, Multifetal / methods*
  • Retrospective Studies
  • Statistics, Nonparametric