Corneal lymphangiogenesis in herpetic stromal keratitis

Abstract

Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally alymphatic cornea, a process that compromises the cornea's immune-privileged state and facilitates herpetic stromal keratitis (HSK). HSK results most commonly from infection by herpes simplex virus-1 (HSV-1) and is characterized by immune- and inflammation-mediated damage to the deep layers of the cornea. Current research demonstrates the potential of anti-lymphangiogenic therapy to decrease and prevent herpes-induced lymphangiogenesis.

Keywords: cornea; herpes simplex virus-1; lymphangiogenesis; neovascularization; vascular endothelial growth factor (VEGF).