Castration-resistant prostate cancer: AUA guideline amendment

J Urol. 2015 Feb;193(2):491-9. doi: 10.1016/j.juro.2014.10.104. Epub 2014 Oct 31.


Purpose: The purpose of this amendment is to incorporate relevant newly-published literature to better provide a rational basis for the management of patients with castration-resistant prostate cancer.

Materials and methods: The original systematic review and meta-analysis of the published literature yielded 303 articles published from 1996 through 2013. This review formed a majority of the guideline statements. Clinical Principles and Expert Opinions were used for guideline statements lacking sufficient evidence-based data. In April 2014, the CRPC guideline underwent amendment based on a second comprehensive literature search, which retrieved additional studies published between February 2013 and February 2014. Thirty-seven studies from this search provided data relevant to the specific treatment modalities for CRPC.

Results: Guideline statements based on six index patients developed to represent the most common scenarios encountered in clinical practice were amended appropriately. The additional literature provided the basis for an update of current supporting text as well as the incorporation of new guideline statements. Specifically, the addition of Radium-223 was placed in the guidelines related to the treatment of CRPC.

Conclusions: Given the rapidly evolving nature of this field, this guideline should be used in conjunction with recent systematic literature reviews and an understanding of the individual patient's treatment goals. Patients' preferences and personal goals should be considered when choosing management strategies. The newly incorporated evidence-based statements supplement the original guideline published in 2013, which provided guidance for the treatment of men with CRPC. This guideline will be continually updated as new literature emerges in the field.

Keywords: prostatic neoplasms; radiopharmaceuticals; radium.

Publication types

  • Practice Guideline
  • Review
  • Systematic Review

MeSH terms

  • Algorithms
  • Forecasting
  • Humans
  • Male
  • Prostatic Neoplasms, Castration-Resistant / therapy*