Repair mechanisms help glioblastoma resist treatment

J Clin Neurosci. 2015 Jan;22(1):14-20. doi: 10.1016/j.jocn.2014.09.003. Epub 2014 Nov 28.

Abstract

Glioblastoma multiforme (GBM) is a malignant and incurable glial brain tumour. The current best treatment for GBM includes maximal safe surgical resection followed by concomitant radiotherapy and adjuvant temozolomide. Despite this, median survival is still only 14-16 months. Mechanisms that lead to chemo- and radio-resistance underpin treatment failure. Insights into the DNA repair mechanisms that permit resistance to chemoradiotherapy in GBM may help improve patient responses to currently available therapies.

Keywords: Base excision repair; Glioma resistance; MGMT; PARP; Temozolomide chemotherapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Neoplasms* / drug therapy
  • Brain Neoplasms* / metabolism
  • Brain Neoplasms* / radiotherapy
  • Brain Neoplasms* / surgery
  • DNA Modification Methylases / metabolism*
  • DNA Repair Enzymes / metabolism*
  • DNA Repair*
  • Glioblastoma* / drug therapy
  • Glioblastoma* / metabolism
  • Glioblastoma* / radiotherapy
  • Glioblastoma* / surgery
  • Humans
  • Poly(ADP-ribose) Polymerases / metabolism*
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Tumor Suppressor Proteins
  • DNA Modification Methylases
  • MGMT protein, human
  • Poly(ADP-ribose) Polymerases
  • DNA Repair Enzymes