Comprehensive analysis suggests simple processes underlying EEG/ERP - demonstration with the go/no-go paradigm in ADHD

G Shahaf; T Fisher; J Aharon-Peretz; H Pratt

doi:10.1016/j.jneumeth.2014.10.016

Comprehensive analysis suggests simple processes underlying EEG/ERP - demonstration with the go/no-go paradigm in ADHD

J Neurosci Methods. 2015 Jan 15:239:183-93. doi: 10.1016/j.jneumeth.2014.10.016. Epub 2014 Nov 1.

Authors

G Shahaf¹, T Fisher², J Aharon-Peretz³, H Pratt⁴

Affiliations

¹ Neurology Department, Rambam Health Care Campus, Haifa, Israel. Electronic address: godeds@gmail.com.
² Cognitive Neurology Unit, Rambam Health Care Campus, Haifa, Israel; Evoked Potentials Laboratory, Technion Israel Institute of Technology, Haifa, Israel.
³ Neurology Department, Rambam Health Care Campus, Haifa, Israel; Cognitive Neurology Unit, Rambam Health Care Campus, Haifa, Israel.
⁴ Evoked Potentials Laboratory, Technion Israel Institute of Technology, Haifa, Israel.

PMID: 25445244
DOI: 10.1016/j.jneumeth.2014.10.016

Abstract

Background: Current basic or more advanced methods for analysis of averaged EEG/ERP are based on assumptions on the underlying processes, which are not necessarily precise.

New method: In this work we present the findings of a method which obviates such assumptions and aims at a comprehensive analysis of the averaged EEG/ERP signal.

Results: For the sake of demonstration we chose the established go/no-go paradigm in the context of ADHD. Our analysis method characterized two spatiotemporally distinct neurophysiologic processes which underlie the sampled signal: one which may be related to attention and the other which may be more related to perception.

Comparison with existing method(s): We show how these processes accord with and provide insight on the waveforms reported in the literature.

Conclusions: Finally we suggest that application of our method on averaged EEG/ERP data sampled from other paradigms may point at a similarly parsimonious set of underlying neurophysiologic processes which underlie the signal.

Keywords: ADHD; Analysis; EEG; ERP; Go/no-go; Oscillations.

MeSH terms

Acoustic Stimulation
Adult
Attention Deficit Disorder with Hyperactivity / diagnosis*
Attention Deficit Disorder with Hyperactivity / physiopathology*
Brain Mapping*
Decision Making / physiology*
Electroencephalography
Evoked Potentials, Auditory / physiology*
Female
Humans
Inhibition, Psychological*
Male
Neuropsychological Tests
Principal Component Analysis
Psychomotor Performance
Reaction Time / physiology