[Polyunsaturated omega-3 fatty acids and systemic lupus erythematosus: what do we know?]

Rev Bras Reumatol. 2014 Nov-Dec;54(6):459-66. doi: 10.1016/j.rbr.2013.12.002. Epub 2014 Sep 28.
[Article in Portuguese]


Various studies have demonstrated the impact of omega-3 fatty acids on the concentration of C reactive protein (CRP), pro-inflammatory eicosanoids, cytokines, chemokines and other inflammatory mediators. Therefore, the supplementation of these types of lipids may represent additional option treatment for chronic systemic diseases, such as Systemic Lupus Erythematous and other rheumatic diseases. The role of these lipids has not been well established, yet. However, it seems there is a direct relationship between its intake and the decrease of the disease clinical manifestations as well as of the inflammatory status of the patients. Thus, the aim of this manuscript is to present a thorough review on the effects of omega-3 fatty acids in patients with SLE. Bibliographic data set as the Medical Literature Analysis and Retrieval System Online (MEDLINE) and Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) were searched using as key words: systemic lupus erythematous (SLE), polyunsaturated fatty acids omega-3, eicosapentanoic acid (EPA), docosahexanoic acid (DHA), antioxidants and diet. Manuscripts published up to September 2013 were included. There were 43 articles related to the topic, however only 15 pertained human studies, with three review articles and 12 clinical studies.

Keywords: Antioxidantes; Antioxidants and diet; Docosahexanoic acid (DHA); Eicosapentanoic acid (EPA); Lúpus eritematoso sistêmico (LES); Polyunsaturated fatty acids omega‐3; Systemic lupus erythematous (SLE); Ácido docosahexaenoico (DHA); Ácido eicosapentaenoico (EPA); Ácidos graxos poli‐insaturados ômega‐3.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Fatty Acids, Omega-3 / therapeutic use*
  • Humans
  • Lupus Erythematosus, Systemic / drug therapy*


  • Anti-Inflammatory Agents
  • Fatty Acids, Omega-3