Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2015 Apr;65(4):349-55.
doi: 10.1016/j.annemergmed.2014.09.025. Epub 2014 Oct 23.

Delayed Sequence Intubation: A Prospective Observational Study

Observational Study

Delayed Sequence Intubation: A Prospective Observational Study

Scott D Weingart et al. Ann Emerg Med. .


Study objective: We investigate a new technique for the emergency airway management of patients with altered mental status preventing adequate preoxygenation.

Methods: This was a prospective, observational, multicenter study of patients whose medical condition led them to impede optimal preintubation preparation because of delirium. A convenience sample of emergency department and ICU patients was enrolled. Patients received a dissociative dose of ketamine, allowing preoxygenation with high-flow nonrebreather mask or noninvasive positive pressure ventilation (NIPPV). After preoxygenation, patients were paralyzed and intubated. The primary outcome of this study was the difference in oxygen saturations after maximal attempts at preoxygenation before delayed sequence intubation compared with saturations just before intubation. Predetermined secondary outcomes and complications were also assessed.

Results: A total of 62 patients were enrolled: 19 patients required delayed sequence intubation to allow nonrebreather mask, 39 patients required it to allow NIPPV, and 4 patients required it for nasogastric tube placement. Saturations increased from a mean of 89.9% before delayed sequence intubation to 98.8% afterward, with an increase of 8.9% (95% confidence interval 6.4% to 10.9%). Thirty-two patients were in a predetermined group with high potential for critical desaturation (pre-delayed sequence intubation saturations ≤93%). All of these patients increased their saturations post-delayed sequence intubation; 29 (91%) of these patients increased their post-delayed sequence intubation saturations to greater than 93%. No complications were observed in the patients receiving delayed sequence intubation.

Conclusion: Delayed sequence intubation could offer an alternative to rapid sequence intubation in patients requiring emergency airway management who will not tolerate preoxygenation or peri-intubation procedures. It is essentially procedural sedation, with the procedure being preoxygenation. Delayed sequence intubation seems safe and effective for use in emergency airway management.

Comment in

  • Delayed Sequence Intubation: Danger in Delaying Definitive Airway?
    Skupski R, Miller J, Binz S, Lapkus M, Walsh M. Skupski R, et al. Ann Emerg Med. 2016 Jan;67(1):143-4. doi: 10.1016/j.annemergmed.2015.08.012. Ann Emerg Med. 2016. PMID: 26707526 No abstract available.
  • In reply.
    Weingart SD, Trueger S, Wong N, Singh N, Rudolph SS. Weingart SD, et al. Ann Emerg Med. 2016 Jan;67(1):144-5. doi: 10.1016/j.annemergmed.2015.08.013. Ann Emerg Med. 2016. PMID: 26707527 No abstract available.

Similar articles

See all similar articles

Cited by 11 articles

See all "Cited by" articles

Publication types

LinkOut - more resources