Increasing uptake of live attenuated influenza vaccine among children in the United States, 2008-2014

Vaccine. 2015 Jan 1;33(1):22-4. doi: 10.1016/j.vaccine.2014.11.006. Epub 2014 Nov 17.


The Advisory Committee on Immunization Practices (ACIP) recommends annual influenza vaccination for all persons in the United States aged ≥6 months. On June 25, 2014, ACIP preferentially recommended live attenuated influenza vaccine (LAIV) for healthy children aged 2-8 years. Little is known about national LAIV uptake. To determine uptake of LAIV relative to inactivated influenza vaccine, we analyzed vaccination records from six immunization information system sentinel sites (approximately 10% of US population). LAIV usage increased over time in all sites. Among children 2-8 years of age vaccinated for influenza, exclusive LAIV usage in the collective sentinel site area increased from 20.1% (2008-09 season) to 38.0% (2013-14). During 2013-14, at least half of vaccinated children received LAIV in Minnesota (50.0%) and North Dakota (55.5%). Increasing LAIV usage suggests formulation acceptability, and this preexisting trend offers a favorable context for implementation of ACIP's preferential recommendation.

Keywords: Child, Preschool; Immunization information systems; Influenza vaccines; Influenza, Human; Registries; Vaccination; Vaccine coverage.

MeSH terms

  • Child
  • Child, Preschool
  • Female
  • Humans
  • Influenza Vaccines / administration & dosage*
  • Influenza, Human / prevention & control*
  • Male
  • United States
  • Vaccination / methods
  • Vaccination / statistics & numerical data*
  • Vaccination / trends*
  • Vaccines, Attenuated / administration & dosage


  • Influenza Vaccines
  • Vaccines, Attenuated