Herpes simplex virus type 1. A cause of the acute retinal necrosis syndrome

Ophthalmology. 1989 Jun;96(6):875-8. doi: 10.1016/s0161-6420(89)32823-5.


The authors have isolated herpes simplex virus type 1 (HSV-1) from the vitreous of two patients with acute retinal necrosis. Clinical and laboratory data suggest that one case represented a primary HSV-1 infection, whereas the other case appeared to be a recurrent HSV-1 infection. In the primary case, changes on magnetic resonance imaging (MRI) suggest spread of the virus posteriorly to both optic tracts and the lateral geniculate ganglia. This case shares many features with the "von Szily" experimental model for HSV retinitis in the mouse.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acyclovir / therapeutic use
  • Adult
  • Electroretinography
  • Fluorescein Angiography
  • Herpes Simplex / complications*
  • Herpes Simplex / drug therapy
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Necrosis / pathology
  • Prednisolone / therapeutic use
  • Retinal Diseases / etiology*
  • Simplexvirus / isolation & purification*
  • Visual Acuity
  • Visual Field Tests
  • Visual Fields
  • Vitrectomy
  • Vitreous Body / microbiology


  • Prednisolone
  • Acyclovir