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, 32 (3), 661-6

Stereochemical Effects of 11-OH-delta 8-THC-dimethylheptyl in Mice and Dogs

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Stereochemical Effects of 11-OH-delta 8-THC-dimethylheptyl in Mice and Dogs

P J Little et al. Pharmacol Biochem Behav.

Abstract

The effects of the enantiomers of 11-hydroxy-delta 8-tetrahydrocannabinol-dimethylheptyl (11-OH-delta 8-THC-DMH) on spontaneous activity, rectal temperature, tail-flick latency, and catalepsy were studied in mice and in the dog static-ataxia model to determine the relative potency of each enantiomer. The (-)-enantiomer was active in all tests between 3-100 micrograms/kg, while the (+)-enantiomer was inactive at 30 mg/kg in the mouse and 1 mg/kg in the dog. The (-)-enantiomer was 100-800 times more potent than delta 9-THC in the mouse. The high degree of enantioselectivity and potency are suggestive of an interaction at a specific site such as a receptor.

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