Anti-platelet or anti-coagulant agent for the prevention of ischemic stroke in patients with end-stage renal disease and atrial fibrillation--a nation-wide database analyses

Int J Cardiol. 2014 Dec 20;177(3):1008-11. doi: 10.1016/j.ijcard.2014.09.140. Epub 2014 Oct 5.


Objective: The risk/benefit profiles of anti-coagulant or anti-platelet agents in patients with end-stage renal disease (ESRD) and atrial fibrillation (AF) remained unclear. We aimed to investigate the stroke risks in these patients with or without anti-coagulant/anti-platelet therapy by using our national database.

Method: By using our national health insurance ESRD claim database, we searched patients with AF, more than 18 years old and without prior history of ischemic stroke. Medication information as well as the events of ischemic stroke, hemorrhagic stroke, and transient ischemic accident during follow-up were identified from the database. Propensity score method was used to match all the potential confounders between patients with and without anti-platelets/warfarin treatment.

Result: A total of 134,410 ESRD patients were identified in the database. Among them, patients with non-valvular AF, over 18 years old, without prior history of ischemic stroke and received monotherapy with anti-platelets (1622) or warfarin (294) served as case groups while patients (2983) without taking any anti-platelets and warfarin served as control groups. The incidences of ischemic stroke or transient ischemic attack (TIA) were not different among the control (6.6%), anti-platelet (6.2%) and warfarin (5.1%) groups in a follow-up period of approximately 4 years. The results remained unchanged after propensity match. Cox-regression analyses also showed no beneficial effect of anti-platelet or warfarin therapy in overall and any subgroups.

Conclusion: In this nationwide cohort analyses, we found that anti-platelet or warfarin treatment could not lower the risk of ischemic stroke in patients with ESRD.

Keywords: Atrial fibrillation; End-stage renal disease; Stroke; Warfarin.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anticoagulants / therapeutic use*
  • Atrial Fibrillation / drug therapy*
  • Atrial Fibrillation / epidemiology
  • Brain Ischemia / epidemiology
  • Brain Ischemia / prevention & control*
  • Cohort Studies
  • Databases, Factual / trends
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Failure, Chronic / drug therapy*
  • Kidney Failure, Chronic / epidemiology
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Stroke / epidemiology
  • Stroke / prevention & control*
  • Taiwan / epidemiology
  • Young Adult


  • Anticoagulants
  • Platelet Aggregation Inhibitors