Corneal thickness of eyes with unilateral age-related macular degeneration

Eur J Ophthalmol. May-Jun 2015;25(3):214-7. doi: 10.5301/ejo.5000544. Epub 2014 Nov 24.

Abstract

Purpose: To compare the central corneal thicknesses (CCT), peripheral corneal thicknesses, and corneal volumes (CV) of the 2 eyes of patients with unilateral age-related macular degeneration (AMD).

Methods: Twenty patients who were diagnosed with unilateral AMD were included in this prospective study for the purpose of making comparison between the diseased and healthy eyes. Optical coherence tomography and fundus fluorescein angiography imaging were applied to all patients in order to confirm and reveal the presence of unilateral AMD. Then, the measurements of CCT, peripheral corneal thickness measured 4 mm distant from the center of the cornea (4 mm CT), and CV of each eye of these patients were obtained through the rotating Scheimpflug corneal topographer.

Results: Wilcoxon signed-rank test did not demonstrate a statistically significant difference between the 2 eyes of patients with unilateral AMD when we compared the CCT and CV of diseased and healthy eyes (p>0.05). However, 4 mm CT of the diseased eyes of these patients were statistically significantly thicker than the healthy eyes (p<0.05).

Conclusions: The significant difference in terms of 4 mm CT between the diseased and healthy eyes of patients with unilateral AMD may demonstrate the possible effect of peripheral corneal thickness on the development of AMD.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cornea / pathology*
  • Female
  • Fluorescein Angiography
  • Humans
  • Male
  • Middle Aged
  • Organ Size
  • Prospective Studies
  • Tomography, Optical Coherence / methods
  • Wet Macular Degeneration / complications*
  • Wet Macular Degeneration / diagnosis