Nucleotide sequence of human papillomavirus type 31: a cervical neoplasia-associated virus

Virology. 1989 Jul;171(1):306-11. doi: 10.1016/0042-6822(89)90545-x.


The nucleotide sequence of human papillomavirus (HPV) 31 DNA (7912 bp) was determined and used to deduce the genomic organization of this cervical cancer-associated virus. Based on comparisons of the HPV 31 DNA sequence to other sequenced HPVs, HPV 31 is a typical papillomavirus most related to HPV 16 (70% identical nucleotides). The E6 and E7 open reading frames (ORF) of HPV 31 contain several potential DNA binding motifs (Cys-X-X-Cys), the locations of which are conserved in all HPVs. The E6 ORF also has the potential to code for an E6* protein. The E7 ORF of HPV31 encodes a polypeptide motif which appears to distinguish HPVs associated with cervical cancer, such as types 16, 18, 31, and 33, from HPVs found primarily in benign lesions, such as types 6 and 11.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • DNA, Viral / genetics
  • Genes, Viral
  • Molecular Sequence Data
  • Papillomaviridae / genetics*
  • RNA Splicing
  • Regulatory Sequences, Nucleic Acid
  • Viral Proteins / genetics


  • DNA, Viral
  • Viral Proteins

Associated data

  • GENBANK/J04353