Diabetes and cancer mortality: a multifaceted association

Ugo Fedeli; Giacomo Zoppini; Nicola Gennaro; Mario Saugo

doi:10.1016/j.diabres.2014.09.027

Diabetes and cancer mortality: a multifaceted association

Diabetes Res Clin Pract. 2014 Dec;106(3):e86-9. doi: 10.1016/j.diabres.2014.09.027. Epub 2014 Oct 5.

Authors

Ugo Fedeli¹, Giacomo Zoppini², Nicola Gennaro³, Mario Saugo³

Affiliations

¹ SER - Regional Epidemiological Department, Veneto Region, Italy. Electronic address: ugo.fedeli@regione.veneto.it.
² Section of Endocrinology and Metabolism, Department of Medicine, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
³ SER - Regional Epidemiological Department, Veneto Region, Italy.

PMID: 25451896
DOI: 10.1016/j.diabres.2014.09.027

Abstract

In a large cohort of subjects with diabetes cancer mortality increased by 30%, possibly due to lower survival, reverse causality, and an etiologic role of diabetes in cancer. A two-fold increased mortality from liver and pancreatic cancer was confirmed in both genders irrespective of follow-up period or disease duration.

Keywords: Cancer risk; Diabetes; Mortality.

MeSH terms

Adult
Aged
Aged, 80 and over
Cohort Studies
Comorbidity
Diabetes Mellitus / epidemiology*
Diabetes Mellitus / etiology
Female
Follow-Up Studies
Humans
Incidence
Liver Neoplasms / epidemiology*
Liver Neoplasms / etiology
Liver Neoplasms / mortality*
Male
Middle Aged
Neoplasms / epidemiology
Neoplasms / etiology
Neoplasms / mortality
Pancreatic Neoplasms / epidemiology*
Pancreatic Neoplasms / etiology
Pancreatic Neoplasms / mortality*
Risk Factors
Survival Rate
Time Factors