Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology Clinical Practice Guidelines

J Clin Oncol. 2015 Jan 10;33(2):209-17. doi: 10.1200/JCO.2014.58.1322. Epub 2014 Dec 1.


Purpose: To provide recommendations on prevention, screening, genetics, treatment, and management for people at risk for hereditary colorectal cancer (CRC) syndromes. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations.

Methods: The Familial Risk-Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guideline published in 2013 on behalf of the European Society for Medical Oncology (ESMO) Guidelines Working Group in Annals of Oncology was reviewed for developmental rigor by methodologists, with content and recommendations reviewed by an ASCO endorsement panel.

Results: The ASCO endorsement panel determined that the recommendations of the ESMO guidelines are clear, thorough, and based on the most relevant scientific evidence. The ASCO panel endorsed the ESMO guidelines and added a few qualifying statements.

Recommendations: Approximately 5% to 6% of patient cases of CRC are associated with germline mutations that confer an inherited predisposition for cancer. The possibility of a hereditary cancer syndrome should be assessed for every patient at the time of CRC diagnosis. A diagnosis of Lynch syndrome, familial adenomatous polyposis, or another genetic syndrome can influence clinical management for patients with CRC and their family members. Screening for hereditary cancer syndromes in patients with CRC should include review of personal and family histories and testing of tumors for DNA mismatch repair deficiency and/or microsatellite instability. Formal genetic evaluation is recommended for individuals who meet defined criteria.

Publication types

  • Practice Guideline

MeSH terms

  • Adenomatous Polyposis Coli / diagnosis*
  • Adenomatous Polyposis Coli / genetics
  • Adenomatous Polyposis Coli / prevention & control
  • Adenomatous Polyposis Coli / therapy*
  • Adenomatous Polyposis Coli Protein / genetics
  • Anticarcinogenic Agents / administration & dosage
  • Chemoprevention / methods
  • Colonoscopy
  • Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis*
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / prevention & control
  • Colorectal Neoplasms, Hereditary Nonpolyposis / therapy*
  • DNA Glycosylases / genetics
  • DNA Mismatch Repair
  • Early Detection of Cancer / methods
  • Genetic Counseling
  • Genetic Predisposition to Disease
  • Genetic Testing*
  • Germ-Line Mutation
  • Heterozygote*
  • Humans
  • Medical History Taking
  • Microsatellite Instability
  • Population Surveillance* / methods
  • Sigmoidoscopy


  • APC protein, human
  • Adenomatous Polyposis Coli Protein
  • Anticarcinogenic Agents
  • DNA Glycosylases
  • mutY adenine glycosylase