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. 2015 Jan;9(1):39-42.
doi: 10.3892/etm.2014.2045. Epub 2014 Nov 3.

Antistress and Antioxidant Effects of Virgin Coconut Oil in vivo

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Free PMC article

Antistress and Antioxidant Effects of Virgin Coconut Oil in vivo

Swee Keong Yeap et al. Exp Ther Med. .
Free PMC article

Abstract

Virgin coconut oil (VCO) has been consumed worldwide for various health-related reasons and some of its benefits have been scientifically evaluated. Medium-chain fatty acids were found to be a potential antidepressant functional food; however, this effect had not been evaluated in VCO, which is rich in polyphenols and medium-chain fatty acids. The aim of this study was to evaluate the antistress and antioxidant effects of VCO in vivo, using mice with stress-induced injury. The antistress effect of VCO (administered per os, at a dose of 10 ml/kg body weight) was evaluated using the forced swim test and chronic cold restraint stress models. VCO was able to reduce immobility time and restore oxidative stress in mice post-swim test. Furthermore, mice treated with VCO were found to exhibit higher levels of brain antioxidants, lower levels of brain 5-hydroxytryptamine and reduced weight of the adrenal glands. Consequently, the serum cholesterol, triglyceride, glucose and corticosterone levels were also lower in VCO-treated mice. These results suggest the potential value of VCO as an antistress functional oil.

Keywords: antioxidant; depression; medium-chain fatty acids.

Figures

Figure 1
Figure 1
Antistress effect of VCO during the forced swim test. (A) Mice fed with 10 ml/kg body weight VCO exhibited reduced immobility time during the forced swim test; (B) Serum SOD and MDA levels post-forced swim test. *Significant difference (P<0.05) compared to the untreated controls. VCO, virgin coconut oil; SOD, superoxide dismutase; MDA, malondialdehyde.

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