Yellow fever

J Clin Virol. 2015 Mar;64:160-73. doi: 10.1016/j.jcv.2014.08.030. Epub 2014 Oct 24.


Yellow fever, a mosquito-borne flavivirus disease occurs in tropical areas of South America and Africa. It is a disease of major historical importance, but remains a threat to travelers to and residents of endemic areas despite the availability of an effective vaccine for nearly 70 years. An important aspect is the receptivity of many non-endemic areas to introduction and spread of yellow fever. This paper reviews the clinical aspects, pathogenesis, and epidemiology of yellow fever, with an emphasis on recent changes in the distribution and incidence of the disease. Recent knowledge about yellow fever 17D vaccine mechanism of action and safety are discussed.

Keywords: Epidemiology; Pathogenesis; Yellow fever.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Africa / epidemiology
  • Endemic Diseases / prevention & control
  • Humans
  • Incidence
  • South America / epidemiology
  • Travel
  • Yellow Fever / epidemiology*
  • Yellow Fever / physiopathology*
  • Yellow Fever Vaccine* / immunology
  • Yellow fever virus / pathogenicity*


  • Yellow Fever Vaccine