Recent advances in research on Crimean-Congo hemorrhagic fever

J Clin Virol. 2015 Mar;64:137-43. doi: 10.1016/j.jcv.2014.08.029. Epub 2014 Oct 22.


Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities.

Keywords: Crimean-Congo hemorrhagic fever; Ecology; Epidemiology.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / therapeutic use
  • Communicable Diseases, Emerging
  • Hemorrhagic Fever Virus, Crimean-Congo / immunology
  • Hemorrhagic Fever Virus, Crimean-Congo / pathogenicity*
  • Hemorrhagic Fever, Crimean / diagnosis*
  • Hemorrhagic Fever, Crimean / epidemiology*
  • Hemorrhagic Fever, Crimean / prevention & control
  • Hemorrhagic Fever, Crimean / therapy
  • Humans
  • Ticks / virology*
  • Viral Vaccines
  • Zoonoses


  • Antiviral Agents
  • Viral Vaccines