Wet-cupping removes oxidants and decreases oxidative stress

Complement Ther Med. 2014 Dec;22(6):1032-6. doi: 10.1016/j.ctim.2014.10.008. Epub 2014 Oct 13.


Objectives: Wet-cupping therapy is one of the oldest known medical techniques. Although it is widely used in various conditions such as acute\chronic inflammation, infectious diseases, and immune system disorders, its mechanism of action is not fully known. In this study, we investigated the oxidative status as the first step to elucidate possible mechanisms of action of wet cupping.

Material and methods: Wet cupping therapy is implemented to 31 healthy volunteers. Venous blood samples and Wet cupping blood samples were taken concurrently. Serum nitricoxide, malondialdehyde levels and activity of superoxide dismutase and myeloperoxidase were measured spectrophotometrically.

Results: Wet cupping blood had higher activity of myeloperoxidase, lower activity of superoxide dismutase, higher levels of malondialdehyde and nitricoxide compared to the venous blood.

Conclusion: Wet cupping removes oxidants and decreases oxidative stress.

Keywords: Antioxidant; Malondialdehyde; Superoxide dismutase; Wet-cupping.

MeSH terms

  • Adult
  • Bloodletting / methods*
  • Female
  • Humans
  • Male
  • Malondialdehyde / blood
  • Nitric Oxide / blood
  • Oxidants / blood
  • Oxidative Stress / physiology*
  • Superoxide Dismutase / blood
  • Young Adult


  • Oxidants
  • Nitric Oxide
  • Malondialdehyde
  • Superoxide Dismutase