A competitive cell fate switch

Dev Cell. 2014 Nov 10;31(3):261-262. doi: 10.1016/j.devcel.2014.10.016. Epub 2014 Nov 10.

Abstract

Whereas tissue development and homeostasis depend on stem cell self-renewal and differentiation, the mechanisms that balance these processes remain incompletely understood. Pan et al. (2014) now show that competitive protein-protein interactions between Bam and COP9 signalosome components regulate cell fate decisions within the Drosophila ovarian germline stem cell lineage.

Publication types

  • Comment

MeSH terms

  • Animals
  • Binding, Competitive*
  • Cell Differentiation*
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / metabolism*
  • Female
  • Male
  • Multiprotein Complexes / chemistry*
  • Multiprotein Complexes / metabolism*
  • Peptide Hydrolases / chemistry*
  • Peptide Hydrolases / metabolism*
  • Stem Cells / cytology*
  • Stem Cells / metabolism*

Substances

  • Multiprotein Complexes
  • Peptide Hydrolases