Pre-exposure prophylaxis for human immunodeficiency virus: the past, present, and future

Amanda D Castel; Manya Magnus; Alan E Greenberg

doi:10.1016/j.idc.2014.08.001

Pre-exposure prophylaxis for human immunodeficiency virus: the past, present, and future

Infect Dis Clin North Am. 2014 Dec;28(4):563-83. doi: 10.1016/j.idc.2014.08.001. Epub 2014 Nov 20.

Authors

Amanda D Castel¹, Manya Magnus², Alan E Greenberg²

Affiliations

¹ Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Avenue, Northwest, 5th Floor, Washington, DC 20052, USA. Electronic address: acastel@gwu.edu.
² Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Avenue, Northwest, 5th Floor, Washington, DC 20052, USA.

PMID: 25455314
DOI: 10.1016/j.idc.2014.08.001

Abstract

This article presents an overview of pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) prevention. The authors describe the past animal and human research that has been conducted that informs our current understanding of PrEP; summarize ongoing research in the area, including describing new regimens and delivery mechanisms being studied for PrEP; and highlight key issues that must be addressed in order to implement and optimize the use of this HIV prevention tool.

Keywords: Adherence; Biomedical intervention; HIV prevention; Implementation; Pre-exposure prophylaxis.

Publication types

Review

MeSH terms

Animals
Anti-HIV Agents / adverse effects
Anti-HIV Agents / therapeutic use*
Clinical Trials as Topic
Female
Forecasting
HIV Infections / prevention & control*
Humans
Male
Pre-Exposure Prophylaxis* / trends

Substances

Anti-HIV Agents