The innate immune response

Immunol Lett. 2014 Dec;162(2 Pt B):95-102. doi: 10.1016/j.imlet.2014.10.010. Epub 2014 Oct 19.


The innate immune response is of prime importance in the immediate recognition and elimination of invading micro-organisms. However, deregulation of this system is clearly associated with the pathogenesis of a wide range of inflammatory diseases. Innate immunity consists of a humoral and a cellular branch, which are closely interacting. An additional level of control is found at the level of neuronal reflexes that can fine-tune these immunological mechanisms.

Keywords: Cellular and humoral branch; Complement system; Granulocytes; Innate immune response; Macrophages; Neuronal regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate / physiology*
  • Inflammation / immunology