Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis

Braz J Otorhinolaryngol. Nov-Dec 2014;80(6):462-9. doi: 10.1016/j.bjorl.2014.08.006. Epub 2014 Aug 27.

Abstract

Introduction: Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. Sjögren's syndrome patients have a higher prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux. Decreased salivary transforming growth factor alpha levels were observed in dyspeptic patients, but there have been no studies in patients with Sjögren's syndrome and laryngopharyngeal reflux.

Objective: To compare the salivary transforming growth factor alpha levels of patients with Sjögren's syndrome and laryngopharyngeal reflux to those of healthy controls.

Methods: This is a prospective controlled study. Twelve patients with Sjögren's syndrome and laryngopharyngeal reflux and 11 controls were prospectively evaluated. Spontaneous and stimulated saliva samples were obtained to establish salivary transforming growth factor alpha concentrations.

Results: The salivary transforming growth factor alpha levels of patients were significantly higher than those of healthy controls. Five patients with laryngopharyngeal reflux also had erosive esophagitis; their salivary transforming growth factor alpha levels were comparable to controls.

Conclusion: Salivary transforming growth factor alpha level was significantly higher in patients with Sjögren's syndrome and laryngopharyngeal reflux when compared to the control group.

Keywords: Epidermal growth factor; Fator de crescimento epidérmico; Fator transformador de crescimento alfa; Laryngopharyngeal reflux; Refluxo laringofaríngeo; Saliva; Sjögren's syndrome; Síndrome de Sjögren; Transforming growth factor alpha; Xerostomia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Case-Control Studies
  • Female
  • Humans
  • Laryngopharyngeal Reflux / metabolism*
  • Middle Aged
  • Prospective Studies
  • Saliva / chemistry*
  • Sjogren's Syndrome / metabolism*
  • Transforming Growth Factor alpha / analysis
  • Transforming Growth Factor alpha / metabolism*

Substances

  • Biomarkers
  • Transforming Growth Factor alpha