Abstract
Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from disruption of the epithelial barrier and associated immune dysregulation in the skin of genetically predisposed hosts. AD generally develops in early childhood, has a characteristic age-dependent distribution and is commonly associated with elevated IgE, peripheral eosinophilia, and other allergic diseases. Medications such as antihistamines have demonstrated poor efficacy in controlling AD-associated itch. Education of patients regarding the primary underlying defects and provision of a comprehensive skin care plan is essential for disease maintenance and management of flares.
Keywords:
Allergy; Atopic dermatitis; Eczema; Hyper-IgE syndrome; Netherton syndrome.
Published by Elsevier Inc.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Adrenal Cortex Hormones / therapeutic use*
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Calcineurin Inhibitors / therapeutic use
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Child
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Dermatitis, Atopic / diagnosis*
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Dermatitis, Atopic / immunology
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Dermatitis, Atopic / physiopathology
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Dermatitis, Atopic / therapy*
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Eczema
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Histamine Antagonists / therapeutic use
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Humans
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Job Syndrome / complications
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Job Syndrome / genetics
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Kaposi Varicelliform Eruption / complications
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Netherton Syndrome / complications
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Netherton Syndrome / genetics
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Pruritus / complications
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Pruritus / drug therapy
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Pruritus / immunology
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Skin / immunology
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Skin / pathology*
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Staphylococcal Skin Infections / complications
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T-Lymphocytes, Regulatory / immunology
Substances
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Adrenal Cortex Hormones
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Calcineurin Inhibitors
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Histamine Antagonists