Mesoporous silica nanoparticles in drug delivery and biomedical applications

Nanomedicine. 2015 Feb;11(2):313-27. doi: 10.1016/j.nano.2014.09.014. Epub 2014 Nov 13.


In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. In this review, we highlight the recent advances in silica-assisted drug delivery systems, including (1) MSN-based immediate/sustained drug delivery systems and (2) MSN-based controlled/targeted drug delivery systems. In addition, we summarize the biomedical applications of MSNs, including (1) MSN-based biotherapeutic agent delivery; (2) MSN-assisted bioimaging applications; and (3) MSNs as bioactive materials for tissue regeneration.

From the clinical editor: This comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug delivery systems. In addition to achieving therapeutic agent delivery, imaging applications and potential use of silica NPs in tissue regeneration are also discussed.

Keywords: Biocompatibility; Biomedical applications; Drug delivery systems; Mesoporous silica nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / therapeutic use
  • Drug Delivery Systems*
  • Humans
  • Nanoparticles / chemistry
  • Nanoparticles / therapeutic use*
  • Porosity
  • Silicon Dioxide / chemistry
  • Silicon Dioxide / therapeutic use*


  • Biocompatible Materials
  • Silicon Dioxide