Chemical approaches to cell reprogramming

Curr Opin Genet Dev. 2014 Oct;28:50-56. doi: 10.1016/j.gde.2014.09.006. Epub 2014 Oct 14.

Abstract

Recent advances in cell reprogramming via employing different sets of factors, which allows generation of various cell types that are beyond the downstream developmental lineages from the starting cell type, provide significant opportunities to study fundamental biology and hold enormous promise in regenerative medicine. Small molecules have been identified to enhance and enable reprogramming by regulating various mechanisms, and provide a highly temporal and tunable approach to modulate cellular fate and functions. Here, we review the latest development in cell reprogramming from the perspective of small molecule modulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cellular Reprogramming / drug effects*
  • Humans
  • Pharmaceutical Preparations / metabolism*
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / drug effects*
  • Small Molecule Libraries / pharmacology*

Substances

  • Pharmaceutical Preparations
  • Small Molecule Libraries