Clinical impact of primary infection with roseoloviruses

Curr Opin Virol. 2014 Dec;9:91-6. doi: 10.1016/j.coviro.2014.09.013. Epub 2014 Oct 14.


The roseoloviruses, human herpesvirus-6A -6B and -7 (HHV-6A, HHV-6B and HHV-7) cause acute infection, establish latency, and in the case of HHV-6A and HHV-6B, whole virus can integrate into the host chromosome. Primary infection with HHV-6B occurs in nearly all children and was first linked to the clinical syndrome roseola infantum. However, roseolovirus infection results in a spectrum of clinical disease, ranging from asymptomatic infection to acute febrile illnesses with severe neurologic complications and accounts for a significant portion of healthcare utilization by young children. Recent advances have underscored the association of HHV-6B and HHV-7 primary infection with febrile status epilepticus as well as the role of reactivation of latent infection in encephalitis following cord blood stem cell transplantation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Herpesvirus 6, Human / physiology
  • Herpesvirus 7, Human / physiology
  • Humans
  • Prevalence
  • Roseolovirus Infections / complications
  • Roseolovirus Infections / epidemiology*
  • Roseolovirus Infections / pathology*
  • Roseolovirus Infections / virology