810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice

Neurosci Res. 2015 Mar;92:86-90. doi: 10.1016/j.neures.2014.11.005. Epub 2014 Nov 25.

Abstract

We explored whether 810nm near-infrared light (NIr) offered neuroprotection and/or improvement in locomotor activity in an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson's disease. Mice received MPTP and 810nm NIr treatments, or not, and were tested for locomotive activity in an open-field test. Thereafter, brains were aldehyde-fixed and processed for tyrosine hydroxylase immunohistochemistry. Our results showed that MPTP-treated mice that were irradiated with 810nm NIr had both greater locomotor activity (∼40%) and number of dopaminergic cells (∼20%) than those that were not. In summary, 810nm (as with 670nm) NIr offered neuroprotection and improved locomotor activity in MPTP-treated mice.

Keywords: Neuroprotection; Substantia nigra; Tyrosine hydroxylase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Count
  • Dopaminergic Neurons / metabolism
  • Dopaminergic Neurons / radiation effects*
  • Infrared Rays*
  • Low-Level Light Therapy
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Motor Activity / radiation effects*
  • Parkinsonian Disorders / metabolism
  • Parkinsonian Disorders / radiotherapy*
  • Pars Compacta / metabolism
  • Pars Compacta / radiation effects*
  • Tyrosine 3-Monooxygenase / analysis

Substances

  • Tyrosine 3-Monooxygenase