Measuring coronary artery calcification: is serum vitamin D relevant?

Atherosclerosis. 2014 Dec;237(2):734-8. doi: 10.1016/j.atherosclerosis.2014.10.087. Epub 2014 Oct 28.


Objectives: To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC).

Methods: A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria.

Results: Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent.

Conclusion: There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.

Keywords: Atherosclerosis; Coronary artery calcification; Serum vitamin D.

Publication types

  • Review

MeSH terms

  • Calcinosis / blood*
  • Calcinosis / epidemiology
  • Coronary Vessels / physiopathology*
  • Cross-Sectional Studies
  • Disease Progression
  • Humans
  • Incidence
  • Longitudinal Studies
  • Prevalence
  • Research Design
  • Vitamin D / blood*


  • Vitamin D