Intranasal immunization with proteoliposomes protects against influenza

Vaccine. 1989 Apr;7(2):147-51. doi: 10.1016/0264-410x(89)90055-8.

Abstract

Worldwide, influenza virus remains a serious disease which has successfully eluded numerous attempts to design a consistently effective vaccine. In part, these attempts have been thwarted because of a lack of basic understanding of the mechanisms which mediate protection and recovery from influenza infection. A better understanding of the roles of secretory antibody, serum antibody and cell mediated immunity vis-à-vis protection and recovery from influenza infection has allowed us more rationally to approach the design and administration of a vaccine for influenza. We have constructed a vaccine composed of glycoproteins from the envelopes of either influenza of Sendai virus embedded in a lipid bilayer (immunosomes) mimicking the presentation of the virus to the cells during natural infection. Intranasal immunization with these immunosomes induces an adequate systemic Ir compared with intramuscular immunization and a superior local IgA response. These animals were specifically protected from virus challenge.

MeSH terms

  • Administration, Intranasal
  • Animals
  • Chick Embryo
  • Immunization
  • Influenza Vaccines / administration & dosage*
  • Lung Diseases / immunology
  • Mice
  • Nose Diseases / immunology
  • Orthomyxoviridae Infections / immunology*
  • Parainfluenza Virus 1, Human
  • Paramyxoviridae Infections / immunology
  • Proteolipids / administration & dosage
  • Proteolipids / analysis
  • Proteolipids / immunology*

Substances

  • Influenza Vaccines
  • Proteolipids
  • proteoliposomes