Cell cycle regulation of mitochondrial function

Curr Opin Cell Biol. 2015 Apr;33:19-25. doi: 10.1016/j.ceb.2014.10.006. Epub 2014 Nov 12.

Abstract

Specific cellular functions, such as proliferation, survival, growth, or senescence, require a particular adaptive metabolic response, which is fine tuned by members of the cell cycle regulators families. Currently, proteins such as cyclins, CDKs, or E2Fs are being studied in the context of cell proliferation and survival, cell signaling, cell cycle regulation, and cancer. We show in this review that cellular, animal and molecular studies provided enough evidence to prove that these factors play, in addition, crucial roles in the control of mitochondrial function; finally resulting in a dual proliferative and metabolic response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cyclin-Dependent Kinases / metabolism
  • Cyclins / metabolism
  • E2F Transcription Factors / metabolism
  • Feedback, Physiological
  • Humans
  • Mitochondria / metabolism
  • Mitochondria / physiology*

Substances

  • Cyclins
  • E2F Transcription Factors
  • Cyclin-Dependent Kinases