Hepatoblastoma in an adult with metastasis to the ovaries

Am J Clin Pathol. 1989 Jul;92(1):110-5. doi: 10.1093/ajcp/92.1.110.


A 19-year-old female had ascites, an enlarged liver, pelvic masses, and an alpha-fetoprotein level of 397,000 micrograms/L with a normal beta-human chorionic gonadotropin serum level. Abdominal exploration revealed a large solitary liver mass with bilateral ovarian masses, and bilateral salpingo-oophorectomy and wedge liver biopsy were performed. The tumor was composed of cords, nests, and pseudorosettes of polyhedral cells with eosinophilic cytoplasm and nuclei with prominent nucleoli. The clinical, light microscopic, and immunocytochemical features indicate that the primary liver neoplasm and ovarian metastases were a purely epithelial hepatoblastoma. To the authors' knowledge, this is the first reported case of this type.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Carcinoma, Hepatocellular / pathology*
  • Carcinoma, Hepatocellular / secondary
  • Female
  • Humans
  • Liver Neoplasms / pathology*
  • Microscopy
  • Microscopy, Electron
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / secondary