Experimental infection of tree shrews (Tupaia belangeri) with Coxsackie virus A16

Dongwuxue Yanjiu. 2014 Nov 18;35(6):485-91. doi: 10.13918/j.issn.2095-8137.2014.6.485.


Coxsackie virus A16 (CA16) is commonly recognized as one of the main human pathogens of hand-foot-mouth disease (HFMD). The clinical manifestations of HFMD include vesicles of hand, foot and mouth in young children and severe inflammatory CNS lesions. In this study, experimentally CA16 infected tree shrews (Tupaia belangeri) were used to investigate CA16 pathogenesis. The results showed that both the body temperature and the percentages of blood neutrophilic granulocytes / monocytes of CA16 infected tree shrews increased at 4-7 days post infection. Dynamic distributions of CA16 in different tissues and stools were found at different infection stages. Moreover, the pathological changes in CNS and other organs were also observed. These findings indicate that tree shrews can be used as a viable animal model to study CA16 infection.

Keywords: Coxsackie virus A16; Infection; Tree shrew.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral
  • Coxsackievirus Infections / pathology
  • Coxsackievirus Infections / veterinary*
  • Coxsackievirus Infections / virology
  • Enterovirus / physiology*
  • Female
  • Tissue Distribution
  • Tupaiidae*
  • Virus Replication


  • Antigens, Viral

Grant support

This work was supported by the National High-Tech R&D Program (2014ZX09102042), the National Natural Science Foundation of China (81373142) and the Natural Science Foundation of Yunnan Province (2012ZA009)