The association between body composition and cystatin C in South Asians: results from the MASALA study

Obes Res Clin Pract. Mar-Apr 2015;9(2):180-3. doi: 10.1016/j.orcp.2014.10.221. Epub 2014 Nov 18.

Abstract

While South Asians have high rates of obesity and kidney disease, little is known about the effect of regional body composition on kidney function. We investigated the association between body composition measures and cystatin C-based estimated glomerular filtration rate (eGFRcysC) in 150 immigrant South Asians. The inverse association between overall adiposity and eGFRcysC was attenuated by C-reactive protein (CRP), while the association of ectopic fat was completely attenuated by metabolic covariates and CRP. In immigrant South Asians, the associations between overall adiposity and ectopic fat with decreased kidney function are largely explained by metabolic alterations and inflammation.

Keywords: Body composition; Cystatin C; Ectopic fat; South Asian.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism*
  • Adiposity
  • Aged
  • Asia / ethnology
  • Asian Continental Ancestry Group*
  • Body Composition*
  • C-Reactive Protein / metabolism
  • California
  • Cross-Sectional Studies
  • Cystatin C / metabolism*
  • Emigrants and Immigrants
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Inflammation / complications
  • Inflammation / metabolism
  • Kidney / metabolism
  • Kidney / physiopathology*
  • Male
  • Metabolic Syndrome / complications
  • Middle Aged
  • Obesity / complications*
  • Obesity / metabolism
  • Obesity / physiopathology
  • Renal Insufficiency, Chronic / metabolism
  • Renal Insufficiency, Chronic / physiopathology

Substances

  • Cystatin C
  • C-Reactive Protein