Prediction of long-term outcome after acute myocardial infarction using circulating miR-145

Scand J Clin Lab Invest. 2015 Jan;75(1):85-91. doi: 10.3109/00365513.2014.981855. Epub 2014 Dec 3.


Background: Recent reports have shown that miR-145 concentration correlates with infarct size. In this paper, we attempt to predict heart failure and cardiovascular death after acute myocardial infarction using circulating miR-145 concentration.

Methods: We assessed 246 patients with first ST-segment-elevation myocardial infarction who underwent successful percutaneous coronary intervention. We measured circulating miR-145, N-terminal fragment of the precursor B-type natriuretic peptide, myocardial-band creatine kinase, and cardiac troponin-I concentrations on day 5 after primary percutaneous coronary intervention and assessed their correlations with long-term clinical outcome.

Results: During the one-year follow-up period, 72 patients experienced primary composite cardiac events (cardiac death or hospitalization for worsening heart failure). Multivariable Cox proportional hazards analysis indicated that circulating miR-145 (hazard ratio 7.174, 95% confidence interval 4.208-12.229); p < 0.0001) was a significant independent predictor of cardiac events after adjustment for multiple confounders.

Conclusion: Circulating miR-145 may be a novel biomarker for predicting long-term outcome after acute myocardial infarction.

Keywords: Heart failure; acute myocardial infarction; biomarker; cardiac death; miR-145.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Disease Progression
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • MicroRNAs / blood*
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Infarction / blood*
  • Myocardial Infarction / mortality
  • Myocardial Infarction / pathology
  • Myocardial Infarction / therapy
  • Proportional Hazards Models
  • Treatment Outcome


  • Biomarkers
  • MIRN145 microRNA, human
  • MicroRNAs