Surface functionalization of quantum dots for biological applications

Ajay Singh Karakoti; Ritesh Shukla; Rishi Shanker; Sanjay Singh

doi:10.1016/j.cis.2014.11.004

Surface functionalization of quantum dots for biological applications

Adv Colloid Interface Sci. 2015 Jan:215:28-45. doi: 10.1016/j.cis.2014.11.004. Epub 2014 Nov 15.

Authors

Ajay Singh Karakoti¹, Ritesh Shukla², Rishi Shanker², Sanjay Singh³

Affiliations

¹ Battelle Science and Technology India Pvt. Ltd., 302, Panchshil Technology Park, Hinjewadi, Pune 411057, India. Electronic address: ajay.karakoti@battelle-india.com.
² Institute of Life Sciences, School of Science and Technology, Ahmedabad University, University Road, Ahmedabad 380009, Gujarat, India.
³ Institute of Life Sciences, School of Science and Technology, Ahmedabad University, University Road, Ahmedabad 380009, Gujarat, India. Electronic address: sanjay.singh@ahduni.edu.in.

PMID: 25467038
DOI: 10.1016/j.cis.2014.11.004

Abstract

Quantum dots are a group of inorganic nanomaterials exhibiting exceptional optical and electronic properties which impart distinct advantages over traditional fluorescent organic dyes in terms of tunable broad excitation and narrow emission spectra, signal brightness, high quantum yield and photo-stability. Aqueous solubility and surface functionalization are the most common problems for QDs employed in biological research. This review addresses the recent research progress made to improve aqueous solubility, functionalization of biomolecules to QD surface and the poorly understood chemistry involved in the steps of bio-functionalization of such nanoparticles.

Keywords: Covalent coupling; Imaging; Quantum dots; Silanization; Surface modifications.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Carriers*
Humans
Ligands
Models, Chemical*
Photochemical Processes
Quantum Dots / chemistry*
Solubility
Surface Properties

Substances

Drug Carriers
Ligands