Triterpenoid glycosides from the leaves of Meliosma henryi

Abdulmagid Alabdul Magid; Hamid Morjani; Dominique Harakat; Claudie Madoulet; Vincent Dumontet; Catherine Lavaud

doi:10.1016/j.phytochem.2014.10.035

Triterpenoid glycosides from the leaves of Meliosma henryi

Phytochemistry. 2015 Jan:109:49-56. doi: 10.1016/j.phytochem.2014.10.035. Epub 2014 Nov 18.

Authors

Abdulmagid Alabdul Magid¹, Hamid Morjani², Dominique Harakat³, Claudie Madoulet⁴, Vincent Dumontet⁵, Catherine Lavaud⁶

Affiliations

¹ Laboratoire de Pharmacognosie, ICMR-UMR 7312, SFR CapSanté, Université de Reims Champagne-Ardenne, Bat. 18, BP 1039, 51687 Reims Cedex 2, France. Electronic address: abdulmagid.alabdulmagid@univ-reims.fr.
² Laboratoire Matrice Extracellulaire Dynamique Cellulaire, ICMR-UMR 7312 CNRS, UFR de Pharmacie, SFR CapSanté, Université de Reims Champagne-Ardenne, 51 rue Cognacq-Jay, 51096 Reims Cedex, France.
³ Service Commun d'Analyses, ICMR-UMR 7312 CNRS, Bat. 18, BP 1039, 51687 Reims Cedex 2, France.
⁴ Laboratoire de Biochimie, Faculté de Pharmacie, Université de Reims Champagne-Ardenne, 51096 Reims Cedex, France.
⁵ Institut de Chimie des Substances Naturelles, UPR 2301 CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
⁶ Laboratoire de Pharmacognosie, ICMR-UMR 7312, SFR CapSanté, Université de Reims Champagne-Ardenne, Bat. 18, BP 1039, 51687 Reims Cedex 2, France.

PMID: 25468712
DOI: 10.1016/j.phytochem.2014.10.035

Abstract

Seven triterpenoid glycosides, named meliosmosides A-G, were isolated from the leaves of Meliosma henryi Diels (Sabiaceae). Their structures were elucidated by different spectroscopic methods including 1D and 2D NMR experiments as well as HRESIMS analysis. Isolated compounds were evaluated for their cytotoxic activity against KB cell line.

Keywords: Cytotoxic activity; Meliosma henryi Diels; Sabiaceae; Triterpenoid glycosides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Cell Line, Tumor
Glycosides / chemistry*
Glycosides / isolation & purification
Humans
Magnoliopsida / chemistry*
Molecular Structure
Plant Leaves / chemistry
Saponins / chemistry*
Saponins / isolation & purification
Triterpenes / chemistry*
Triterpenes / isolation & purification

Substances

Antineoplastic Agents, Phytogenic
Glycosides
Saponins
Triterpenes
meliosmoside