Abstract
New inhibitors of Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase, KS-501 and KS-502 were isolated from a fungus, Sporothrix sp. KAC-1985. Inhibitory concentration causing 50% inhibition (IC50) values of KS-501 and KS-502 for bovine brain enzyme were 1.8 and 4.3 microM, respectively. The compounds exhibited no or weak inhibition for calmodulin-independent cyclic-nucleotide phosphodiesterases and protein kinase C.
MeSH terms
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2',3'-Cyclic-Nucleotide Phosphodiesterases / antagonists & inhibitors*
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Calcium / metabolism*
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Calmodulin / metabolism
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Chromatography, Gel
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Chromatography, Thin Layer
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Fermentation
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Hydroxybenzoates / biosynthesis*
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Hydroxybenzoates / isolation & purification
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Hydroxybenzoates / pharmacology
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Molecular Structure
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Sporothrix / metabolism*
Substances
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Calmodulin
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Hydroxybenzoates
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KS 502
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KS 501
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2',3'-Cyclic-Nucleotide Phosphodiesterases
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Calcium