Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza Roxb. inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes
- PMID: 25471012
- DOI: 10.1007/s12272-014-0525-z
Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza Roxb. inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes
Abstract
Four sesquiterpenes were isolated from the rhizome of Curcuma xanthorrhiza Roxb.: furanodiene (1), germacrone (2), furanodienone (3), and 13-hydroxygermacrone (4). Importantly, this was the first time compounds 1 and 4 were isolated from this plant. The chemical structures of these compounds were determined using 1D- and 2D-nuclear magnetic resonance, infrared spectroscopy, and electron ionization mass spectrometry analyses. Among the isolated compounds, compounds 2 and 4 inhibited UVB-induced upregulation of the mRNA and protein expression levels of MMP-1, MMP-2, and MMP-3 in human keratinocytes (HaCaT). Moreover, this upregulation occurred in a dose-dependent manner over the range of 1-10 μM for each compound.
Keywords: Curcuma xanthorrhiza; Germacrane; HaCaT; MMPs; NMR; UVB.
Similar articles
-
Anti-inflammatory sesquiterpenes from Curcuma zedoaria.Nat Prod Res. 2006 Jun;20(7):680-5. doi: 10.1080/14786410500462900. Nat Prod Res. 2006. PMID: 16901812
-
Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.Fitoterapia. 2012 Jul;83(5):864-71. doi: 10.1016/j.fitote.2012.03.017. Epub 2012 Mar 21. Fitoterapia. 2012. PMID: 22465508
-
Sesquiterpenes from Curcuma comosa.J Nat Med. 2009 Jan;63(1):102-4. doi: 10.1007/s11418-008-0282-8. Epub 2008 Jul 29. J Nat Med. 2009. PMID: 18663560
-
Javanese Turmeric (Curcuma xanthorrhiza Roxb.): Ethnobotany, Phytochemistry, Biotechnology, and Pharmacological Activities.Evid Based Complement Alternat Med. 2021 Jun 11;2021:9960813. doi: 10.1155/2021/9960813. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34194529 Free PMC article. Review.
-
Xanthorrhizol, a potential anticancer agent, from Curcuma xanthorrhiza Roxb.Phytomedicine. 2022 Oct;105:154359. doi: 10.1016/j.phymed.2022.154359. Epub 2022 Jul 29. Phytomedicine. 2022. PMID: 35933899 Review.
Cited by
-
Turmeric Essential Oil Constituents as Potential Drug Candidates: A Comprehensive Overview of Their Individual Bioactivities.Molecules. 2024 Sep 5;29(17):4210. doi: 10.3390/molecules29174210. Molecules. 2024. PMID: 39275058 Free PMC article. Review.
-
Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects.Biomolecules. 2024 Mar 23;14(4):387. doi: 10.3390/biom14040387. Biomolecules. 2024. PMID: 38672405 Free PMC article. Review.
-
Two Traditional Chinese Medicines Curcumae Radix and Curcumae Rhizoma: An Ethnopharmacology, Phytochemistry, and Pharmacology Review.Evid Based Complement Alternat Med. 2016;2016:4973128. doi: 10.1155/2016/4973128. Epub 2016 Feb 18. Evid Based Complement Alternat Med. 2016. PMID: 27057197 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
