Antiangiogenic VEGF-A in peripheral artery disease

Joshua M Boucher; Victoria L Bautch

doi:10.1038/nm.3767

Antiangiogenic VEGF-A in peripheral artery disease

Nat Med. 2014 Dec;20(12):1383-5. doi: 10.1038/nm.3767.

Authors

Joshua M Boucher¹, Victoria L Bautch²

Affiliations

¹ Department of Biology and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
² 1] Department of Biology and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

PMID: 25473918
DOI: 10.1038/nm.3767

Abstract

Vascular endothelial growth factor A (VEGF-A) is a potent proangiogenic cytokine elevated in patients with peripheral artery disease (PAD). A new study links impaired vascular regrowth in PAD to increased expression of an antiangiogenic splice variant of VEGF-A.

Publication types

Comment

MeSH terms

Animals
Humans
Neovascularization, Physiologic / physiology*
Peripheral Arterial Disease / metabolism*
Vascular Endothelial Growth Factor A / metabolism*

Substances

Vascular Endothelial Growth Factor A

Grants and funding

R01 HL043174/HL/NHLBI NIH HHS/United States